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Communication | Special issue | Vol 13, No. 1, 1979, pp.197-202
Published online, 1st January, 1970
DOI: 10.3987/S-1979-01-0197
Synthesis of 3-(1-Methyl-1,2,3,4-tetrazol-5-yl and 2-Methyl-1,3,4-thiadiazol-5-yl-oxymethyl)-3-cephem Derivatives

Morio Kishi, Hiroyuki Ishitobi, Wataru Nagata, and Teruji Tsuji*

*Shionogi Research Laboratories, Shionogi & Co. Ltd., Fukushima-ku, Osaka 553-0002, Japan

Abstract

Cephem derivatives possessing a heterocyclic oxymethyl group at position 3 were synthesized by two methods as the benzhydryl 1 or p-nitrobenzyl esters 2 and 3. However, removal of the ester protecting groups to obtain the free acids was unsuccessful.