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Communication | Special issue | Vol 13, No. 1, 1979, pp.157-162
Published online, 1st January, 1970
DOI: 10.3987/S-1979-01-0157
Synthesis of 3’-Epi-4’-deoxykanamycin B through 3’-Epi-3’,4’-anhydro Intermediate.

Eiichi Akita,* Yukio Horiuchi, and Takeo Miyazawa

*Library, Pharmaceutical Research Center, Meiji Seika Kaisha Ltd., 760 Morooka-cho, Kohoku-ku, Yokohama 222-8567, Japan

Abstract

3’-Epi-4’-deoxykanamycin B was synthesized from a protected derivative of 3’-O-tosylkanamycin B by the reductive ring opening of the assumed intermediate epoxide with sodium borohydride, and the structure of the objective compound was confirmed by PMR, molecular rotation value of its copper complex, and periodate oxidation of its hydrolysate.