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Communication | Special issue | Vol 10, No. 1, 1978, pp.269-276
Published online, 1st January, 1970
DOI: 10.3987/S-1978-01-0269
Reactivity of Imidazo [1,2-b]pyridazine 1-Oxides

Kazue Satoh and Tadashi Miyasaka*

*School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan


The treatment of either imidazo[1,2-b]pyridazines (III) or their 1-oxides (III) with excess organic peracid resulted in the oxidative cleavage of imidazole moiety to give 3-(N-acylhydroxylamino)pyridazines (IV). The bromination and nitration of II gave the corresponding 3-substituted N-oxides (VII, IX, X, and XI). Rearrangement reaction of II with phosphoryl chloride or acetic anhydride afforded the deoxygenated 7-substituted imidazopyridazines, XII and XIII, respectively.