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Communication | Special issue | Vol 10, No. 1, 1978, pp.221-228
Published online, 1st January, 1970
DOI: 10.3987/S-1978-01-0221
Nucleophilic Reactions of 5,6-Dihydronicotinic Acid Esters and a Novel Method for the Preparation of 1,4,5,6-Tetrahydropyridine-3-carboxylic Acid Esters

Ulrich Renner*

*Pharmaceuticals Division, Research Department, Ciba-Geigy Limited, CH-4002 Basel, Switzerland


Reaction of 1,5-diaminopentan-3-one V with ethyl acetoacetate yielded diazaspiro-undecadiene-dicarboxylic acid ester VI by a one-step synthesis. Novel 4-aroyl- 1,4,5,6-tetrahydropyridine-3-carboxylic acid esters XI and condensed analogs XI11 have been prepared by cycloaddition of ethyl acetoacetate to α-methylene-6-aminopropiophenones or their cyclized analogs respectively.