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Communication | Special issue | Vol 7, No. 2, 1977, pp.877-884
Published online, 1st January, 1970
DOI: 10.3987/S-1977-02-0877
A Novel Synthesis of 4-Hydroxypyrimidine Derivatives

Edward Grochowski* and Zygmunt Eckstein

*Institute of Organic Chemistry, Polish Academy of Sciences, ul. Kasprzaka 44/52, P.O.Box 58, PL-01-224 Warszawa 42, Poland


It was found that 2,2,2-trichloroethylidene-N,N’-bis-phenylacetamide derivatives in alcoholic potassium hydroxide undergo a cyclization to give 5-aryl-6-arymethyl-2-dichloromethyl-4-hydroxypyrimidines.