Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Special issue | Vol 7, No. 1, 1977, pp.119-122
Published online, 1st January, 1970
DOI: 10.3987/S-1977-01-0119
The Synthesis of (3S,5S)-5-Hydroxyhexahydropyridazine-3-carboxylic acid

Cedric H. Hassall* and Kuzhalmannam L. Ramachandran

*Roche Products Ltd, Welwyn Garden City, Herts, U.K.


The compound named in the title, a naturally occurring amino acid, has been synthesised from the Diels-Alder adduct of penta-2,4-dienoic acid to phthalazinedione, through successive oxidation with mercuric acetate, hydrogenation with Rh-Al2O3 catalyst, acid hydrolysis, resolution with quinine, and hydrazinolysis.