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Communication | Special issue | Vol 5, No. 1, 1976, pp.331-337
Published online, 1st January, 1970
DOI: 10.3987/S-1976-01-0331
A Novel Oxidation of Qunaldine N-Oxide

Hirohisa Saito, Hideki Muro, Seitaro Saeki, and Masatomo Hamana*

*Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan


Treatment of quinaldine N-oxide (5) with thallium triacetate or lead tetraacetate in acetic acid or/and acetic anhydride leads to the formation of 2-acetoxymethylquinoline N-oxide (2), diacetate of quinaldaldehyde (3), quinaldaldehyde (4) and quinaldaldehyde N-oxide (5). The selective preparation of 2, 3, 4 or 5 can be effected by adjusting the reaction conditions.