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Communication | Special issue | Vol 5, No. 1, 1976, pp.293-297
Published online, 1st January, 1970
DOI: 10.3987/S-1976-01-0293
Synthesis of 3-Hydroxy Cephems

Hans Rudolf Pfaendler,* Phillip Andrew Rossy, Jacques Gosteli, and Robert Burns Woodward

*Woodward Research Institute, 4002 Basel, Switzerlamd


The compounds 2, readily produced from natural penicillin V, are converted to 3-hydroxy cephems 1 through an efficient three-step reaction sequence.