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Communication | Special issue | Vol 5, No. 1, 1976, pp.239-244
Published online, 1st January, 1970
DOI: 10.3987/S-1976-01-0239
Studies on Potential Antitumor Agents I. Thiosemicarbazones of p-Chlorophenyl- and m-Chlorophenylpyridine-2-carboxaldehydes

Chao-Tung Chen,* Shih-Fong Chen, and Shwu-JIuan Lee

*Institutue of Chemistry, Academia Sinica, 128, Yan-Chiu-Yuan Road, Sec II, Nankang, Taipei,11529, Taiwan, R.O.C.

Abstract

Thiosemicarbazones of eight p- and m-chlorophenylpyridine-2-carboxaldehydes have been synthesized. The biological activity of these compounds was evaluated by animal test. 4-(p-Chlorophenyl)pyridine-2-carboxaldehyde thiosemicarbazone was found to possess potential antitumor activity with low toxicity.