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Communication | Special issue | Vol 5, No. 1, 1976, pp.183-188
Published online, 1st January, 1970
DOI: 10.3987/S-1976-01-0183
Synthesis and Structure Assignments of Diethyl cis- and trans-5-Ethyl-2-oxo-4-piperidinemalonate

Tozo Fujii,* Shigeyuki Yoshifuji, and Kyoko Ikeda

*Faculty of Pharmaceutical Scicences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-0934, Japan


The Michael addition of diethyl malonate to 1-acetyl-5-ethyl-5,6-dihydro-2(1H)-pyridone (III) produced an 85 : 15 mixture of the trans- (IVa) and the cis-isomer (IVb) of the title lactam diester. The configuration of both isomers has been established by chemical interrelation of them with substances of known stereochemistry.