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Communication | Special issue | Vol 8, No. 1, 1977, pp.229-236
Published online, 1st January, 1970
DOI: 10.3987/S(S)-1977-01-0229
An Approach to the Synthesis of Intermediate Sized Oligoribonucleitides

Alexander F. Markham, Tetsuo Miyake, Eiko Ohtuska, and Morio Ikehara*

*Faculty of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Toyonaka, Osaka 560-0043, Japan

Abstract

A mixed phosphodiester-phosphotriester stepwise addition method for the synthesis of oligoribonucleotides is described. Using this method CpCpCpCpCpG and UpCpCpGpG which correspond to bases 66 to 71 and 61 to 65 of E. coli tRNAfMet thave been synthesized.