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Communication | Special issue | Vol 8, No. 1, 1977, pp.211-219
Published online, 1st January, 1970
DOI: 10.3987/S(S)-1977-01-0211
Studies on the Structure-Activity Relationship of Adrenergic β-Mimetic Benzylamine Derivatives. III. 9-Aryl-1H-2,3,7,8,9,10-tetrahydrobenzo[d,e]quinolines

Shiro Yamamura,* Kuniyuki Oda, Seiichi Saito, Michio Yamazaki, Yoshio Iwasawa, Akio Kiyomoto, and Kyuji Abe

*Biological and Chemical Research Laboratories, Tanabe Seiyaku Co.Ltd., 2-2-50, Kawagishi, Toda, Saitama 335-8505, Japan

Abstract

The synthesis and adrenergic activity of stereoisomeric 5,6-dihydroxy-9-aryl-1H-2,3,7,8,9,10-hexahydrobenzo[d,e]quinolines (4a, 4b, 4’a, and 4’b), rigid structures related to the compounds (1, 2, and 3), are presented.