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Communication | Special issue | Vol 8, No. 1, 1977, pp.199-205
Published online, 1st January, 1970
DOI: 10.3987/S(S)-1977-01-0199
Chemical Ionization Mass Spectra of New Macrolide Antibiotics, M-4365 A2 and G2

Makoto Suzuki,* Ken-ichi Harada, Naohito Takeda, and Akira Tatematsu

*Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tenpaku, Nagoya 468-8503, Japan


Ammonia and isobutane chemical ionization (CI) mass spectra of basic 16-membered ring macrolide antibiotics, M-4365 A2 and G2, are described.
The spectra show protonated molecular ions (MH+, m/e 582 and 566, respectively) as the base peak in all cases. Cleavage of desosamine moiety from M-4365 A2 and G2 affords the protonated (m/e 176)- and oxonium (m/e 174)-type ions. These ions are shown to be useful in the structural characterization of new macrolide antibiotics.