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Communication | Special issue | Vol 8, No. 1, 1977, pp.159-164
Published online, 1st January, 1970
DOI: 10.3987/S(S)-1977-01-0159
The Reaction of Quinazoline with Aromatic Compounds in Dilute Sulfuric Acid

Takeo Higashino,* Yutaka Kawade, and Eisaku Hayashi

*Shizuoka College of Pharmacy, 2-2-1, Oshika, shizuoka-shi, 442 Shizuoka, Japan


The reaction of quinazoline with aromatic compounds substituted by electron donating groups such as aniline, N-methyl-, N,N-dimethylaniline, phenol, anisole, and indole in dilute sulfuric acid was carried out. Thus, the corresponding 4-aryl-3,4-dihydroquinazoline (IIa-IIf) was obtained.
Some of the compounds (II) were converted into 4-arylquinazoline (IV) by the oxidation with potassium ferricyanide.