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Communication | Special issue | Vol 8, No. 1, 1977, pp.153-157
Published online, 1st January, 1970
DOI: 10.3987/S(S)-1977-01-0153
Reactive D-Alanyl-D-alanine Peptide Derives from Cycloserine

Akira Tsuji, Tsukinaka Yamana,* Shigeru Matsutani, and Naoki Tsuji

*Faculty of Pharmaceutical Scicences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-0934, Japan

Abstract

N-Phenylacetyl-2-(1’-carboxyethyl)cycloserine (1) was synthesized and its acylation was examined. Like penicillin and cephalosporin, the L-cycloserine derivative (1a) could be regarded as D-alanyl-D-alanine peptide containing a reactive peptide bond, but it displayed no antibacterial activity.