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Communication | Special issue | Vol 11, No. 1, 1978, pp.139-147
Published online, 1st January, 1970
DOI: 10.3987/S(N)-1978-01-0139
The Reaction of Amides with Diethylthiocarbamoyl Chloride: A New Procedure for the Preparation of Nitriles and Thioamides

Masaru Ogata* and Hiroshi Matsumoto

*Shionogi Research Laboratories, Shionogi & Co. Ltd., Fukushima-ku, Osaka 553-0002, Japan

Abstract

Primary amides reacted with diethylthiocarbamoyl chloride to give their nitriles, and also tertiary amides gave their thioamides smoothly. In the presence of amines, the above reactions yielded the amidines, quinazolines or ureas, according to a variety of amides and amines used.