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Communication | Special issue | Vol 11, No. 1, 1978, pp.101-104
Published online, 1st January, 1970
DOI: 10.3987/S(N)-1978-01-0101
A New Synthesis of 1,2,4-Oxadiazoles

Joel Polo* and Yuan L. Chow

*Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby B. C. V5A 1S6, Canada


Irradiation of N-nitroso-N-acyl-α-amino acids under weakly basic condition led to the formation of substituted 1,2,4-oxadiazoles in competition with slow basic decompositions of nitrosamides. The cyclization was shown to occur from the C-nitroso compound 5 but not from its tautomeric oxime 8.