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Communication | Special issue | Vol 18, No. 1, 1982, pp.77-82
Published online, 1st January, 1970
DOI: 10.3987/S(B)-1982-01-0077
Facile Synthesis of N-Substituted 1H-Azepine Derivatives

Nagaraj R. Ayyangar,* Ramesh B. Bambal, and Ananda G. Lugade

*National Chemical Laboratory, Dr. Homi Bhabha road, Pune-411 008, India


The facile synthesis of N-sulphonyl and N-ethoxycarbonyl substituted 1H-azepines in high yields by the pressure-induced sulphonylnitrene insertion reaction or, in anhydrous solvents, the 1,3-dipolar azide addition reaction with aromatic substrates containing electron-withdrawing substituents (e.g. dimethyl terephthalate) are described. The probable sequences of reactions involved in the two cases have been indicated.