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Review | Regular issue | Vol 48, No. 9, 1998, pp.1943-1958
Published online, 1st January, 1970
DOI: 10.3987/REV-98-502
Use of Enzymes in Preparation of Enantiopure 1,4-Dihydropyridines

Stefan Marchalín, Miloslav Chudík, Vladimír Mastihuba, and Bernard Decroix*

*Laboratoire de Chimie, Faculté des Sciences et Techniques, Université du Havre, 25, rue Philippe Lebon, BP 540, 76058 Le Havre Cedex, France

Abstract

Various chemoenzymatic routes to optically pure biologically active dihydropyridines are reviewed. The review is focused on influence on the biotransformation of the main in vivo enzymatic activity of the hydrolase (lipase, esterase, protease), the microorganism source of the lipase and the substituents of the 1,4-dihydropyridine ring, as well as the physicochemical properties of the solvent and the nature of the nucleophile. The influence of these variables in the desymmetrisation of prochiral diesters or in the resolution of racemic compounds is analyzed.