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Review | Regular issue | Vol 27, No. 7, 1988, pp.1755-1802
Published online, 1st January, 1970
DOI: 10.3987/REV-88-384
Conversion of Beta-Lactams to Versatile Synthons via Molecular Rearrangement and Lactam Cleavage

Maghar S. Manhas,* Dilip R. Wagle, Julian Chiang, and Ajay K. Bose

*Department of Chemistry and Chemical Engineering, Stevens Institute of Technology, Castle Point on the Hudson, Hoboken, NJ 07030, U.S.A.


Substituted β-lactams can be synthesized by a variety of methods some of which are stereocontrolled and diastereoselective. Because of their high chemical reactivity and their propensity for molecular rearrangement, these β-lactams can serve as efficient syntnons for racemic or optically active forms of diverse types of natural products such as carbohydrates, alkaloids, amino acids and oligopeptides.