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Review | Special issue | Vol 74, No. 1, 2007, pp.101-124
Published online, 30th November, 2007
DOI: 10.3987/REV-07-SR(W)4
Methodology for the Synthesis of Pyridines and Pyridones: Development and Applications

Marco A. Ciufolini* and Bryan K. Chan

*Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver B.C., V6T 1Z1, Canada

Abstract

We review some reactions devised in our laboratory for the rapid assembly of pyridines and pyridones. Applications of the new methods in the total synthesis of lavendamycin, pyridoacridine and phenanthroizidine alkaloids (pyridine chemistry), and of camptothecin, nothapodytine B and streptonigrone (pyridone-forming reactions) are described.