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Review | Regular issue | Vol 75, No. 6, 2008, pp.1305-1320
Published online, 1st February, 2008
DOI: 10.3987/REV-07-627
Palladium-Mediated Intramolecular Biaryl Coupling Reaction for Natural Product Synthesis

Hitoshi Abe* and Takashi Harayama*

*Faculty of Pharmaceutical Science, Okayama University, 1-1-1 Tsushima-naka, Okayama 700-8530, Japan


An intramoleculer biaryl coupling reaction is a useful technique for the synthesis of certain types of heterocyclic compounds. This short review describes recent advances in the Pd-mediated intramolecular C-C bond formation reaction between two aromatic rings, and several examples of natural product synthesis using this reaction. The mechanistic aspect of this reaction is also explained.