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Review | Regular issue | Vol 75, No. 3, 2008, pp.493-529
Published online, 20th November, 2007
DOI: 10.3987/REV-07-620
Organocatalytic Asymmetric Synthesis Using Proline and Related Molecules. Part 1

Hiyoshizo Kotsuki,* Hideaki Ikishima, and Atsushi Okuyama

*Laboratory of Natural Product Chemistry, Faculty of Science, Kochi University, Akebono-cho, Kochi 780-8520, Japan

Abstract

Organocatalytic asymmetric synthesis has been extensively studied and several important procedures for preparing optically active organic compounds have been developed. Research in this area has progressed rapidly in the last ten years. This review addresses the most significant advances in asymmetric synthesis using proline and related chiral organocatalysts mainly focusing on aldol reactions from the viewpoint of synthetic interests. This includes (1) proline-catalyzed aldol reactions, (2) proline-related chiral catalysts, and (3) other types of amino acid catalysts.