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Review | Regular issue | Vol 68, No. 11, 2006, pp.2403-2422
Published online, 22nd September, 2006
DOI: 10.3987/REV-06-610
Quaternary Benzo[c]phenanthridines Sanguinarine and Chelerythrine: a Review of Investigations from Chemical and Biological Studies

Zdenek Dvorák, Vlastimil Kubán, Borivoj Klejdus, Jan Hlavác, Jaroslav Vicar, Jitka Ulrichová, and Vilím Simánek*

*Department of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacky University Olomouc, Hnevotinska 3, 77515 Olomouc, Czech Republic


Sanguinarine and chelerythrine are intensively studied biologically active alkaloids for their potentially useful medicinal properties, such as antimicrobial, antiinflammatory, and antitumoral activities. This article aims to review critically recent literature published on the chemical behavior, synthesis, analytical methods and biotransformation of both alkaloids.