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Review | Regular issue | Vol 68, No. 10, 2006, pp.2177-2202
Published online, 22nd August, 2006
DOI: 10.3987/REV-06-608
1,3-Dipolar Cycloadditions in Aqueous Media

Giorgio Molteni

*University of Milan, Department of Organic and Industrial Chemistry, via Golgi 19, 20133 Milan, Italy


1,3-Dipolar cycloadditions in aqueous media represents a useful, non conventional protocol in the synthesis of a variety of five-membered heterocycles. In addition, water as the solvent may significantly enhance cycloaddition rates and/or stereoslectivities. The literature data on this subject are reviewed in a systematic way, with an emphasis to improvements with respect to cycloadditions performed in the usual, non-aqueous conditions.