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Review | Regular issue | Vol 68, No. 8, 2006, pp.1723-1759
Published online, 27th June, 2006
DOI: 10.3987/REV-06-607
1,2,4-Triazolo[1,5-a][1,3,5]triazines (5-Azapurines): Synthesis and Biological Activity

Anton V. Dolzhenko, Anna V. Dolzhenko, and Wai-Keung Chui*

*Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore


The present review gives an account of the various synthetic routes to the 5-aza-analogue of purine-1,2,4-triazolo[1,5-a][1,3,5]triazine nucleus and polyfused systems bearing this heterocyclic core. Data concerning biological activity of the compounds with 1,2,4-triazolo[1,5-a][1,3,5]triazine skeleton are also discussed.