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Review | Regular issue | Vol 65, No. 9, 2005, pp.2203-2219
Published online, 15th July, 2005
DOI: 10.3987/REV-05-599
Luotonin A: A Lead toward Anti-Cancer Agent Development

Zhongze Ma,* Yoshio Hano,* and Taro Nomura

*School of Pharmaceutical Sciences, Toho University, 2-2-1, Miyama, Funabashi, Chiba 274-8510, Japan

Abstract

Luotonin A, a novel pyrroloquinazolinoquinoline alkaloid isolated from the aerial parts of Peganum nigellastrum Bunge, showed a cytotoxic activity against mouse leukemia cells (P-388) and an inhibitory activity against topoisomerase I and II. This review covers the isolation, structural determination, synthesis and biological activity of luotonin A and its related derivatives. A water-soluble topoisomerase I inhibitor, 14-azacamptothecin analogous to luotonin A and camptothecin, was also discussed.