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Review | Regular issue | Vol 65, No. 7, 2005, pp.1741-1749
Published online, 25th March, 2005
DOI: 10.3987/REV-05-597
Recent Advances in Macrosphelide Synthesis

Yuji Matsuya and Hideo Nemoto*

*Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, Toyama 930-0194, Japan


Natural macrosphelides are known as potent cell-cell adhesion inhibitors, which have novel three ester linkages in their 16-membered macrocyclic skeleton. In this review, recent synthetic studies of macrosphelides and relating compounds are surveyed, mainly including our approaches.