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Review | Regular issue | Vol 65, No. 6, 2005, pp.1491-1513
Published online, 3rd March, 2005
DOI: 10.3987/REV-04-595
Synthesis of Polynuclear Aromatic Compounds Incorporating a Fused Thiophene Ring

Tarun Kanti Pradhan and Asish De*

*Department of Organic Chemistry, Indian Asociation for the Cultivation of Science, Jadavpur, Calcutta 700 032, India

Abstract

The present review gives an account of the various synthetic routes to polynuclear heteroaromatic compounds incorporating a fused thiophene ring which include analogs of several biologically active compounds. These compounds are synthesized using a suitably functionalised benzo[b]thiophene as the core and applying various annulation reactions. Directed metalation was extensively used both for functionalisation and in annulation reactions.