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Review | Regular issue | Vol 60, No. 3, 2003, pp.689-716
Published online, 6th January, 2003
DOI: 10.3987/REV-02-561
Terpenoid Coumarins of the Genus Ferula

Mohamed H. Abd El-Razek, Shinji Ohta, and Toshifumi Hirata*

*Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashi-hiroshima, Hiroshima 739-8526, Japan


Chemical studies on the plants of the genus Ferula (Apiaceae) show the presence of many compounds belonging mainly to the groups of monoterpene coumarins, sesquiterpene coumarins, sesquiterpenes, furanocoumarins and aromatic compounds. Biological studies reveal significant activities, such as an anti-HIV activity, inhibition of cytokine release and early events of carcinogenesis. Extracts of some species of Ferula have long been used in folk medicine for treating various diseases, possess an antimicrobial and estrogenic actions, and are natural plant growth inhibitors and stimulators.