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Review | Special issue | Vol 56, No. 1-2, 2002, pp.711-741
Published online, 1st January, 1970
DOI: 10.3987/REV-01-SR(K)4
Biotransformations of Alkaloids: A Challenge

Wolf-Rainer Abraham* and Grigor Spassov

*GBF - National Research Center for Biotechnology, Research Group Microbial Ecology, Mascheroder Weg 1, D-38124 Braunschweig, Germany


The biotransformation of various alkaloids is reviewed. Special attention is paid to problems in microbial transformations and the different solutions offered by different authors. The biosynthetic potential of the strains selected for biotransformations is compared to the reaction observed in microbal oxidation. An outlook to future developments in other areas, especially from active site modelling, genomics and microbial ecology, are discussed which may contribute to problems in biotransformations.