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Review | Regular issue | Vol 53, No. 8, 2000, pp.1839-1868
Published online, 1st January, 1970
DOI: 10.3987/REV-00-535
Synthesis of Substituted Quinazolin-4(3H)-ones and Quinazolines via Directed Lithiation

Gamal A. El-Hiti*

*Department of Chemistry, Faculty of Science, Tanta University, Tanta 31527, Egypt

Abstract

Various quinazolin-4(3H)-ones and quinazolines were successfully lithiated using different lithiating reagents at low temperatures. Reactions of lithio reagents thus obtained with a variety of electrophiles afforded the corresponding substituted derivatives in very good yields.