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Paper | Regular issue | Vol 26, No. 12, 1987, pp.3159-3164
Published online, 1st January, 1970
DOI: 10.3987/R-1987-12-3159
Nucleophilic Substitution Reactions on Sulfur by n-Butyllithium 2

Toshiyasu Mase and Kiyoshi Murase

*Central Research Laboraories, Yamanouchi Pharmaceutical Co., Ltd., 1-1-8, Azusawa, Itabashi-ku, Toyko 174-0051, Japan


The reaction of some 2-phenylimidazo[2,1-b]benzothiazoles (1) with organometal reagents (n-BuLi, n-Bu2CuLi, i-Pr2NLi and EtMgBr) has been investigated. Two reagents (n-BuLi and n-Bu2CuLi) induced the nucleophilic substitution reaction on sulfur of 1 and to give the C-S bond cleaved compounds.