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Paper | Regular issue | Vol 26, No. 11, 1987, pp.2887-2894
Published online, 1st January, 1970
DOI: 10.3987/R-1987-11-2887
Bis(4-methyl-2-thiazolyl)guanidines. Preparation and Physicochemical Properties

Reiko Yoda and Yoshikazu Matsushima

*Faculty of Pharmaceutical Sciences, Kyoritsu College of Pharmacy, 1-5-30, Shiba-koen, Minato-ku, Tokyo 105-8512, Japan

Abstract

Eighteen N-substituted and N,N-disubstituted N’, N”-bis (4-methyl-2-thiazolyl) guanidin were prepared by the reaction of N,N’-bis(4-methyl-2-thiazolyl)-S-methylisothiourea with amines. Their ultraviolet, infrared, 1H- and 13C-nuclear magnetic resonance and mass spectral data supported the structures.