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Communication | Regular issue | Vol 26, No. 11, 1987, pp.2853-2856
Published online, 1st January, 1970
DOI: 10.3987/R-1987-11-2853
Reaction of 2,4-Diphenyl-1,3,5-triazine Derivatives with Nucleophiles

Hiroshi Yamanaka, Setsuya Ohba, and Shoetsu Konno

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan


The addition of hydrogen cyanide to 2,4-diphenyl-1,3,5-triazine (1) followed by spontaneous oxidation of the adduct gave 4,6-diphenyl-1,3,5-triazine-2-carbonitrile (4) in considerable yield. Similarly, 1 reacted with various active methylene compounds in the presence of sodium hydride to give the corresponding 2-substituted 4,6-diphenyl-1,3,5-triazines (8a-c). Additionally, the condensation of 2-chloro-4,6-diphenyl-1,3,5-triazine (2) with benzaldehyde in the presence of 1,3-dimethylbenzimidazolium iodide under basic conditions, gave the corresponding 2-benzoyl-1,3,5-triazine (9).