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Paper | Regular issue | Vol 26, No. 10, 1987, pp.2711-2716
Published online, 1st January, 1970
DOI: 10.3987/R-1987-10-2711
Palladium-catalyzed Cross-coupling of Phenylboronic Acid with Heterocyclic Aromatic Halides

Johannes Stavenuiter, Martin Hamzink, Rob van der Hulst, Gijsbert Zomer, Gerard Westra, and Erik Kriek

*National Institute of Public Health and Environmental Hygiene, P.O.Box 1, 3720 BA Bilthoven, The Netherlands


The coupling reaction of bromo- and - iodopyridines 1 with phenylboronic acid (2a) by Pd(Ph3 P)4 provides a convenient route to phenylpyridines, even when electrondonating or - withdrawing substituents are present. The method is also successful for the preparation of other phenylated N-containing heterocycles 5 as phenylquinolines and -pyrimidines.