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Paper | Regular issue | Vol 26, No. 10, 1987, pp.2691-2701
Published online, 1st January, 1970
DOI: 10.3987/R-1987-10-2691
Catalytic Hydrogenation of 2,5-Dialkylpyrazines and 3,6-Dialkyl-2-hydroxypyrazines

Akihiro Ohta, Yukari Okuwaki, Tsuyoshi Komaru, Mieko Hisatome, Yasushi Yoshida, Jun Aizawa, Yumi Nakano, Hiroko Shibata, Takuya Miyazaki, and Tokuhiro Watanabe

*Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan


Hydrogenation of several 2,5-dialkylpyrazines and 3.6-dialkyl-2-hydroxypyrazines was achieved in the presence of platinum oxide. In the former cases, the corresponding trans piperazines were mainly obtained. In the latter cases, the products were further treated with lithium aluminum hydride to give mainly the cis isomers.