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Communication | Regular issue | Vol 26, No. 10, 1987, pp.2573-2578
Published online, 1st January, 1970
DOI: 10.3987/R-1987-10-2573
Phaeanthine-2’a-N-oxide and Pycmanilline, New Bisbenzylisoquinoline Alkaloids from Pycnarrhena manillensis

Jacinto C. Regalado, Jr., Cong-yuan Gao, Emil Fu, Fu-tyan Lin, Mei-chao Lin, Lan K. Wong, and Paul L. Schiff, Jr.

*Department of Pharmacognosy, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, U.S.A.


Chromatography of an ethanolic extract of pycrarrhena manillensis over silica gel afforded phaeanthine-2’α-N-axide (1) and pycmanilline (2) which were characterized as new bisbenzylisoquinoline alkaloids by a consideration of physicochemical data and the utilization of simple chemical reactions. Phaeathine-2’α-N-axide (1) was reduced to phaeanthine (3) while pycmanilline (2), a secobisbenzyliso-quinoline alkaloid, was prepared via oxidation of phaeanthine (3).