Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Regular issue | Vol 26, No. 7, 1987, pp.1765-1770
Published online, 1st January, 1970
DOI: 10.3987/R-1987-07-1765
A Promising Cyclization of the 3-Arylidene-6-arylmethyl-2,5-piperazinedione to Construct Tricyclic Lactam as an Intermediate to Saframycin Synthesis

Akinori Kubo, Naoki Saito, Madoka Nakamura, Koreharu Ogata, and Shin-ichiro Sakai

*Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan


Regioselective reduction of the 3-arylidene-6-arylmethyl-2,5-piperazinedione (7b) at the C-2 position, followed by effective intramolecular cyclization to afford the tricyclic lactam (10b)is described. The structure of 16 as an intermediate to saframycin synthesis is confirmed by an X-ray crystallographic analysis.