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Paper | Regular issue | Vol 26, No. 6, 1987, pp.1549-1555
Published online, 1st January, 1970
DOI: 10.3987/R-1987-06-1549
Pyridindolol Analogues. Synthesis of 3-Hydroxymethyl-1-(polyhydroxyalkyl)-β-carbolines

Nico P. Willard, Erwin Dorland, and Upendra K. Pandit

*Organic Chemistry Department, University of Amsterdam, Nieuwe Achtergracht 129, 1018 WS Amsterdam, The Netherlands


Peracetylated (D)-glucose, (D)-galactose, (D)-ribose, (L)-ardbinose and (D)-xylose have been subjected to a Pictet-Spengler cycllsation with methyl tryptophanate to give β-carboline derivatives which have been converted to a series of pyridindolol analogues.