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Review | Regular issue | Vol 26, No. 5, 1987, pp.1333-1344
Published online, 1st January, 1970
DOI: 10.3987/R-1987-05-1333
The N-Carboxylic Acids of Nitrogen Heterocycles

Alan R. Katritzky, Hassan Faid-Allah, and Charles M. Marson

*Center for Drug Discovery, College of Pharmacy, University of Florida, Gainesville, Florida 32611-7200, U.S.A.


Nitrogenous heterocyclic carbamic acids posseas considerable stability and can frequently be isolated as free acids. A variety of synthetic methods are available and the expected range of derivatives is formed. Recently, such N-carboxylic acids have been demonstrated to form useful protecting/activating groups in metalation reactions.