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Communication | Regular issue | Vol 26, No. 5, 1987, pp.1197-1202
Published online, 1st January, 1970
DOI: 10.3987/R-1987-05-1197
A Short Step Synthesis of Clavicipitic Acids from 4-Cyanomethylindole

Masakatsu Matsumoto, Hisako Kobayashi, and Nobuko Watanabe

*Sagami Central Research Center, 4-4-1 Nishi-Ohnuma, Sagamihara, Kanagawa 229-0012, Japan

Abstract

4-(3-methyl-1-oxo-2-buten-1-y1)indole (3) was efficiently synthesized from 4-cyanomethyl-l-(p-toluenesulfonyl)indole by alkylation with 2-methyl-2-buten-1-yl tosylate and by successive aerobic oxidation and deprotection of N-tosyl group. The acylindole 3 was used for a short step synthesis of clavicipitic acids (4).