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Communication | Regular issue | Vol 26, No. 5, 1987, pp.1185-1188
Published online, 1st January, 1970
DOI: 10.3987/R-1987-05-1185
Synthesis of Substituted 1,2,3,4-Tetrahydro-6-methyl-2-oxo-5-pyrimidinecarboxylic Acid Esters: The Biginelli Condensation Revisited

Brian C. O‘Reilly and Karnail S. Atwal

*Department of Chemistry, Isfahan University, Isfahan 81746-73441, Iran


A general synthesis of substituted 1,2,3,4-tetrahydro-6-methyl-2-oxo-5- pyrimidinecarboxylic acid esters from 2-methylene-3-oxobutanoic acid esters and O-methylisourea hydrogen sulfate is reported.