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Communication | Regular issue | Vol 26, No. 4, 1987, pp.875-878
Published online, 1st January, 1970
DOI: 10.3987/R-1987-04-0875
A New Route to 4-Oxygenated β-Carbolines: The Total Synthesis of Crenatine

Yasuoki Murakami, Yuusaku Yokoyama, Chiyoko Aoki, Chiemi Miyagi, Toshiko Watanabe, and Taichi Ohmoto

*School of Pharmaceutical Sciences, Toho University, 2-2-1, Miyama, Funabashi, Chiba 274-8510, Japan

Abstract

Crenatine, a new type of β-carboline alkaloid having an oxygen function at its C4-position, was synthesized using ethyl 1-benzylindole-2-carboxylate as a starting material via cyclization of C2-substituent to C3-position of indole nucleus and AlCl3-catalyzed debenzylation for N-protected indoles.