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Paper | Regular issue | Vol 26, No. 3, 1987, pp.751-754
Published online, 1st January, 1970
DOI: 10.3987/R-1987-03-0751
Synthesis of Diazepino-fused Heterocycles: Reactions with 4-Chlorobutyl Isocyanate

Ahmed Kamal, Narendra A. V. Reddy, and Prahlad B. Sattur

*Regional Research Laboratory, Hyderabad 500 007, India


The reactlon of anthranilonitrile with 4-chlorobutyl isocyanate gives urea 3, which undergoes a double cyclization to form 2,3,4,5-tetrahydro[1,3]- diazepino[1,2-c]quinazolin-7(8H)-one, upon heating or treatment with a base. Similarly, the reaction of 2-hydroxybenzonitrile with 4-chlorobutyl isocyanate and upon cyclization affords 2,3,4,5-tetrahydro[1,3]diazepino[1,2-c][1,3]benzoxazin-7-one.