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Communication | Regular issue | Vol 26, No. 3, 1987, pp.633-640
Published online, 1st January, 1970
DOI: 10.3987/R-1987-03-0633
Synthesis of Novel Fluorine-containing Cephalosporins

Kiyoharu Nishide, Takeo Kobori, Daiei Tunemoto, and Kiyoshi Kondo

*Sagami Central Research Center, 4-4-1 Nishi-Ohnuma, Sagamihara, Kanagawa 229-0012, Japan


Cephalosporins with (E)- and (Z)-7β-[2-(2-aminothiazol-4- yl)-4,4,4-trifluoro-2-butenamido] side chain were synthesized. Of these, the cephalosporin 12e having pyridiniomethyl group at the 3-position exhibited excellent activity against most of microorganisms tested.