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Communication | Regular issue | Vol 26, No. 3, 1987, pp.585-589
Published online, 1st January, 1970
DOI: 10.3987/R-1987-03-0585
Synthesis of 5-Substituted Pyrimidines through ortho-Directed Lithiation Reactions

Akimori Wada, Junpei Yamamoto, and Shoichi Kanatomo

*School of Pharmacy, Hokuriku University, 3-Ho, Kanagawa machi, Kanazawa 920-1181, Japan

Abstract

Treatment of 2- and/or 4-substituted pyrimidine with LiTMP in ether at 0°C, followed by quenching with various electrophiles afforded the corresponding 5-substituted pyrimidines.