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Communication | Regular issue | Vol 26, No. 2, 1987, pp.355-358
Published online, 1st January, 1970
DOI: 10.3987/R-1987-02-0355
Palladium Catalyzed Coupling of 5-Hydroxyuracil Trifluoromethanesulfonates (Triflates) with Alkenes and Alkynes

Kosaku Hirota, Yukio Kitade, Yoshiaki Isobe, and Yoshifumi Maki

*Labolatory of Medicinal Chemistry, Gifu Pharmaceutical University, 6-1 Mitahora-higashi 5-chome, Gifu 502-8585, Japan


Cross coupling of 5-hydroxyuracil triflates (1) with alkenes and alkynes in the presence of a palladium catalyst and triphenylphosphine affords 5-vinyluracils (2) and 5-alkynyluracils (3), respectively, in good yields. Coupling of the triflate (1a) with organocopper reagents [R2Cu(CN)Li2] is also described.