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Paper | Regular issue | Vol 26, No. 1, 1987, pp.95-100
Published online, 1st January, 1970
DOI: 10.3987/R-1987-01-0095
Reaction of L-Tryptophan with Alkyl Isocyanates

Miguel F. Braña, Mercedes Garrido, Maria L. López Rodríguez, and M. José Marcillo

*Departamento de Química Orgánica I., Facultad de Química, Universidad Complutense de Madrid, Ciudad Universitaria, E-28040 Madrid, Spain


L-Tryptophan reacts with alkyl isocyanates to give the corresponding hydantoins 2,4-7. Alternatively, the reactions with ethyl, propyl and lsopropyl isocyanates in acetone provide the corresponding 2-[(3-alkyl-4,4-dimethyl-2-oxo)-1,3-diazetidinyl]-3 -(3-indoly) prpionic acids 3, 8 and 9.