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Communication | Regular issue | Vol 26, No. 1, 1987, pp.1-4
Published online, 1st January, 1970
DOI: 10.3987/R-1987-01-0001
Demethylations of Methoxypyridazines with Amines

Hiromu Nagashima, Hirohisa Oda, Takahisa Hayakawa, and Kenji Kaji

*Gifu Pharmaceutical University, 6-1 Mitahora-higashi 5-chome, Gifu 502-8585, Japan

Abstract

When various pyridazines possessing the chlorine and methoxy group at 3, 4 and 5-position were treated with 10 eq. of primary and secondary amines, demethylation was observed. Demethylation of 2-methyl-methoxy-3(2H)-pyridazinones was also investigated.